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A team effort blocks the ribosome in its tracks

A complex of PUF (named after founding members Pumilio and Fem-3 binding factor) and Argonaute proteins can stall translation elongation on bound mRNAs by interacting with eEF1A and inhibiting its GTPase activity.

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Figure 1: Role of eEF1A in translation.
Figure 2: Translational regulation by PUF−Ago−eEF1A.

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Correspondence to Amy E Pasquinelli.

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Pasquinelli, A. A team effort blocks the ribosome in its tracks. Nat Struct Mol Biol 19, 133–134 (2012). https://doi.org/10.1038/nsmb.2236

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