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Claims and counterclaims of X-chromosome compensation

Is there upregulation of the single active X chromosome in mammals or not? Recent studies take different points of view.

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Figure 1: Ohno's proposed evolution of mammalian sex chromosomes.

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Correspondence to James A Birchler.

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Birchler, J. Claims and counterclaims of X-chromosome compensation. Nat Struct Mol Biol 19, 3–5 (2012). https://doi.org/10.1038/nsmb.2218

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