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New insights in the mechanism of microRNA-mediated target repression

Nature Structural & Molecular Biology volume 18, pages 1181–1182 (2011)Cite this article

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The microRNA-induced silencing complex (miRISC) protein TNRC6 (also called GW182) uses dispersed tryptophan-containing repeats in unstructured regions to recruit the CCR4–NOT nuclease complex leading to mRNA deadenylation and inhibition of translation initiation according to new research.

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Figure 1: Domain structure of representative members of the TNRC6 protein family.
Figure 2: Model of TNRC6 interaction with the CCR4–NOT and PAN2–PAN3 deadenylase complexes in humans.

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Authors and Affiliations

  1. Markus Hafner, Manuel Ascano Jr. and Thomas Tuschl are at the Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, The Rockefeller University, New York, New York, USA.,

    Markus Hafner, Manuel Ascano Jr & Thomas Tuschl

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  1. Markus Hafner
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  2. Manuel Ascano Jr
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  3. Thomas Tuschl
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Correspondence to Thomas Tuschl.

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Competing interests

T.T. is cofounder and scientific advisor to Alnylam Pharmaceuticals and an advisor to Regulus Therapeutics.

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Hafner, M., Ascano, M. & Tuschl, T. New insights in the mechanism of microRNA-mediated target repression. Nat Struct Mol Biol 18, 1181–1182 (2011). https://doi.org/10.1038/nsmb.2170

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