Mechanistic details about complexin's contradictory double life as both a facilitator and an inhibitor of SNARE-mediated synaptic vesicle fusion have been challenging to uncover. A series of studies in this issue addresses the problem by revealing a switchable complexin conformation in which fusion arrest occurs when complexin clamps neighboring SNAREs.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Li, F. et al. Nat. Struct. Mol. Biol. 18, 941–946 (2011).
Kümmel, D. et al. Nat. Struct. Mol. Biol. 18, 927–933 (2011).
Krishnakumar, S.S. et al. Nat. Struct. Mol. Biol. 18, 934–940 (2011).
Brose, N. Traffic 9, 1403–1413 (2008).
Reim, K. et al. Cell 104, 71–81 (2001).
Huntwork, S. & Littleton, J.T. Nat. Neurosci. 10, 1235–1237 (2007).
Giraudo, C.G., Eng, W.S., Melia, T.J. & Rothman, J.E. Science 313, 676–680 (2006).
Schaub, J.R., Lu, X., Doneske, B., Shin, Y.K. & McNew, J.A. Nat. Struct. Mol. Biol. 13, 748–750 (2006).
Tang, J. et al. Cell 126, 1175–1187 (2006).
Chen, X. et al. Neuron 33, 397–409 (2002).
Xue, M. et al. Nat. Struct. Mol. Biol. 14, 949–958 (2007).
Giraudo, C.G. et al. J. Biol. Chem. 283, 21211–21219 (2008).
Malsam, J. et al. Proc. Natl. Acad. Sci. USA 106, 2001–2006 (2009).
Giraudo, C.G. et al. Science 323, 512–516 (2009).
Lu, B., Song, S. & Shin, Y.K. J. Mol. Biol. 396, 602–609 (2010).
Yang, X., Kaeser-Woo, Y.J., Pang, Z.P., Xu, W. & Sudhof, T.C. Neuron 68, 907–920 (2010).
Weninger, K., Bowen, M.E., Choi, U.B., Chu, S. & Brunger, A.T. Structure 16, 308–320 (2008).
Xue, M. et al. Nat. Struct. Mol. Biol. 17, 568–575 (2010).
Choi, U.B. et al. Nat. Struct. Mol. Biol. 17, 318–324 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Weninger, K. Complexin arrests a neighbor. Nat Struct Mol Biol 18, 861–863 (2011). https://doi.org/10.1038/nsmb.2118
Published:
Issue Date:
DOI: https://doi.org/10.1038/nsmb.2118
This article is cited by
-
The impact of bacterial infection on mast cell degranulation
Immunologic Research (2011)