News & Views | Published:

Complexin arrests a neighbor

Nature Structural & Molecular Biology volume 18, pages 861863 (2011) | Download Citation

Mechanistic details about complexin's contradictory double life as both a facilitator and an inhibitor of SNARE-mediated synaptic vesicle fusion have been challenging to uncover. A series of studies in this issue addresses the problem by revealing a switchable complexin conformation in which fusion arrest occurs when complexin clamps neighboring SNAREs.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Nat. Struct. Mol. Biol. 18, 941–946 (2011).

  2. 2.

    et al. Nat. Struct. Mol. Biol. 18, 927–933 (2011).

  3. 3.

    et al. Nat. Struct. Mol. Biol. 18, 934–940 (2011).

  4. 4.

    Traffic 9, 1403–1413 (2008).

  5. 5.

    et al. Cell 104, 71–81 (2001).

  6. 6.

    & Nat. Neurosci. 10, 1235–1237 (2007).

  7. 7.

    , , & Science 313, 676–680 (2006).

  8. 8.

    , , , & Nat. Struct. Mol. Biol. 13, 748–750 (2006).

  9. 9.

    et al. Cell 126, 1175–1187 (2006).

  10. 10.

    et al. Neuron 33, 397–409 (2002).

  11. 11.

    et al. Nat. Struct. Mol. Biol. 14, 949–958 (2007).

  12. 12.

    et al. J. Biol. Chem. 283, 21211–21219 (2008).

  13. 13.

    et al. Proc. Natl. Acad. Sci. USA 106, 2001–2006 (2009).

  14. 14.

    et al. Science 323, 512–516 (2009).

  15. 15.

    , & J. Mol. Biol. 396, 602–609 (2010).

  16. 16.

    , , , & Neuron 68, 907–920 (2010).

  17. 17.

    , , , & Structure 16, 308–320 (2008).

  18. 18.

    et al. Nat. Struct. Mol. Biol. 17, 568–575 (2010).

  19. 19.

    et al. Nat. Struct. Mol. Biol. 17, 318–324 (2010).

Download references

Author information

Affiliations

  1. Keith R. Weninger is in the Department of Physics, North Carolina State University, Raleigh, North Carolina, USA.

    • Keith R Weninger

Authors

  1. Search for Keith R Weninger in:

Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Keith R Weninger.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nsmb.2118

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing