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Complexin arrests a neighbor

Mechanistic details about complexin's contradictory double life as both a facilitator and an inhibitor of SNARE-mediated synaptic vesicle fusion have been challenging to uncover. A series of studies in this issue addresses the problem by revealing a switchable complexin conformation in which fusion arrest occurs when complexin clamps neighboring SNAREs.

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Figure 1: Complexin modulates SNARE-driven membrane fusion of synaptic vesicles.
Figure 2: Schematics illustrating the configuration of complexin.

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Correspondence to Keith R Weninger.

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Weninger, K. Complexin arrests a neighbor. Nat Struct Mol Biol 18, 861–863 (2011). https://doi.org/10.1038/nsmb.2118

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