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RAF-isotype switching: from B to C through PDE

Nature Structural & Molecular Biology volume 18, pages 517518 (2011) | Download Citation

A new study reveals that rewiring of MAPK signaling in cells expressing mutant RAS includes ERK-mediated BRAF inactivation and the concomitant activation of CRAF, partly through amplification by the phosphodiesterase 4 isoform.

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Author information

Affiliations

  1. Eric Lau and Ze'ev Ronai are in the Signal Transduction Program at the Sanford Burnham Medical Research Institute, La Jolla, California, USA.

    • Eric Lau
    •  & Ze'ev Ronai

Authors

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Ze'ev Ronai.

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DOI

https://doi.org/10.1038/nsmb.2063

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