Abstract
Assumptions of restricted flexibility upon binding conflict with emerging data showing that motion can increase, decrease or stay the same within molecular complexes. Now, calculations of entropic contributions from dynamics at specific positions in a complex suggest that increases in motion can dominate the free energy of association in certain cases.
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Forman-Kay, J. The 'dynamics' in the thermodynamics of binding. Nat Struct Mol Biol 6, 1086–1087 (1999). https://doi.org/10.1038/70008
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DOI: https://doi.org/10.1038/70008
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