Buried water molecules play a pivotal structural and energetic role in mediating interactions between a bacterial oligopeptide transporter protein and its ligands.
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Tame, J., Sleigh, S., Wilkinson, A. et al. The role of water in sequence-independent ligand binding by an oligopeptide transporter protein. Nat Struct Mol Biol 3, 998–1001 (1996). https://doi.org/10.1038/nsb1296-998
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DOI: https://doi.org/10.1038/nsb1296-998