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Formation of the hinge helix in the lac represser is induced upon binding to the lac operator

Nature Structural Biology volume 3, pages 916919 (1996) | Download Citation

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NMR studies of the free and DNA-bound states of the lac represser headpiece show that formation of the hinge helix requires protein–protein interactions and occurs only when the represser binds to the full lac operator.

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Author information

Affiliations

  1. Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands

    • Christian A.E.M. Spronk
    • , Monique Slijper
    • , Robert Kaptein
    •  & Rolf Boelens
  2. Gorlaeus Laboratory, University of Leiden, Leiden, The Netherlands

    • Jacques H. van Boom
  3. kaptein@nmr.chem.ruu.nl

    • Robert Kaptein

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DOI

https://doi.org/10.1038/nsb1196-916

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