The crystal structure of the haemopexin-like C-terminal domain of gelatinase A reveals that it is a four-bladed β-propeller protein. The four blades are arranged around a channel-like opening in which Ca2+ and a Na-Cl+ion pair are bound.
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References
Birkedal-Hansen, H. et al. Crit. Rev. Oral biol. Med. 4, 197–250 (1993).
Stetler-Stevenson, W.G., Aznavoorian, S. & Liotta, L.A. A. Rev. Cell Biol. 9, 541–573 (1993).
Stetler-Stevenson, W.G. Cancer Metastasis Rev. 9, 289–303 (1990).
Howard, E.W. & Banda, M.J. J. biol. Chem. 266, 17972–17977 (1991).
Goldberg, G.I. et al. Proc. natn. Acad. Sci. U.S.A. 86, 8207–8211 (1989).
Sato, H. et al. Nature 370, 61–65 (1994).
Strongin, A. et al. J. biol. Chem. 270, 5331–5338 (1995).
Murphy, G. et al. Biochem. J. 283, 637–641 (1992).
Li, J. et al. Structure 15, 541–549 (1995).
Faber, H.R. et al. Structure 15, 551–559 (1995).
Laskowski, R.A., MacArthur, W.M., Moss, D.S. & Thornton, J.M. J. appl. Crystallogr. 26, 283–291 (1992).
Otwinowski, Z. in Isomorphous Replacement and Anomolous Scattering 80–86 (Daresbury Laboratory, Warrington, UK; 1991).
SERC Daresbury Laboratory. CCP4, a Suite of Programs for Protein Crystallography. (Warrington, UK; 1979).
Jones, T.A., Zou, J.Y., Cowan, S.W. & Kjeldgaard, M. Acta crystallogr. A 47, 110–119 (1991).
Brunger, A.T. XPLOR (Version 3.1) manual (1992).
Evans, S.V. SETOR: J. molec. Graphics 11, 134–145 (1993).
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Libson, A., Gittis, A., Collier, I. et al. Crystal structure of the haemopexin-like C-terminal domain of gelatinase A. Nat Struct Mol Biol 2, 938–942 (1995). https://doi.org/10.1038/nsb1195-938
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DOI: https://doi.org/10.1038/nsb1195-938
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