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Getting hotter with RNA

Nature Structural Biology volume 9, pages 795–796 (2002)Cite this article

Results from in vitro selection studies reveal that enhanced ribozyme stability can be achieved through a small number of substitutions, which primarily improve the packing interactions in the molecular interior.

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Figure 1: Free energy plots for the stability of RNA as a function of [Mg2+] and temperature.

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Authors and Affiliations

  1. the Department of Biochemistry and Molecular Biology and the Institute for Biophysical Dynamics, University of Chicago, Chicago, 60637, Illinois, USA

    Tobin R. Sosnick

  2. the Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, 60637, Illinois, USA

    Tao Pan

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  1. Tobin R. Sosnick
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  2. Tao Pan
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Sosnick, T., Pan, T. Getting hotter with RNA. Nat Struct Mol Biol 9, 795–796 (2002). https://doi.org/10.1038/nsb1102-795

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