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Protein dynamic studies move to a new time slot

Nature Structural Biology volume 8, pages 912–914 (2001)Cite this article

Many proteins frequently undergo structural rearrangement to complete their functions. Ligand entry and binding are often associated with some degree of localized disorder. Indeed, low populations of disordered excited states may help drive such processes. Characterization of these states is vital to understanding the mechanisms of many biological functions.

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Figure 1: Ribbon diagram of the C-terminal domain of the L99A T4 lysozyme mutant (red) complexed with benzene (white).
Figure 2: The results of an AutoDock study using a grid encompassing the entire HIV-1 protease surface.

References

  1. Palmer, A.G., Kroenke, C.D. & Loria, J.P Methods Enzymol. 339, 204–238 (2001).

    Article  CAS  Google Scholar 

  2. Kay, L.E. Nature Struct. Biol. 5, 513–517 (1998).

    Article  CAS  Google Scholar 

  3. Palmer, A.G. Curr. Opin. Struct. Biol. 7, 732–737 (1997).

    Article  CAS  Google Scholar 

  4. Voet, D. & Voet, J.G., Biochemistry (John Wiley & Sons, New York; 1990).

    Google Scholar 

  5. Fersht, A. Enzyme structure and mechanism, 2nd ed. (Freeman & Co., New York; 1995).

    Google Scholar 

  6. Jackson, S.E. Folding Des. 3, 81–91 (1998).

    Article  Google Scholar 

  7. Roder, H. & Shastry, M.C.R. Curr. Opin. Struct. Biol. 9, 620–626 (1999).

    Article  CAS  Google Scholar 

  8. McCammon, J.A. & Harvey, S.C., Dynamics of proteins and nucleic acids (Cambridge University Press, Cambridge, UK; 1987).

    Book  Google Scholar 

  9. Akke, M., Bruschweiler, R. & Palmer, A.G. J. Am. Chem. Soc. 115, 9832–9833 (1993).

    Article  CAS  Google Scholar 

  10. Yang, D. & Kay, L.E. J. Mol. Biol. 263, 369–382 (1996)

    Article  CAS  Google Scholar 

  11. Li, Z., Raychaudhuri, S. & Wand, A.J. Protein Sci. 5, 2647–2650 (1996).

    Article  CAS  Google Scholar 

  12. Denisov, V.P., Venu, K., Peters, J., Horlein, H.D. & Halle, B. J. Phys. Chem. 101, 9380–9389 (1997).

    Article  CAS  Google Scholar 

  13. Mulder, F.A.A., Mittenmaier, A., Hon, B., Dahlquist, F.W. & Kay, L.E. Nature Struct. Biol. 8, 932–935 (2001).

    Article  CAS  Google Scholar 

  14. Eriksson, A.E., Baase, W.A., Wozniak, J.A. & Matthews, B.W. Nature 355, 371–373 (1992).

    Article  CAS  Google Scholar 

  15. Morton, A. & Matthews, B.W. Biochemistry 34, 8576–8588 (1995).

    Article  CAS  Google Scholar 

  16. Zhang, X-j., Wozniak, J.A. & Matthews, B.W. J. Mol. Biol. 250, 527–532 (1995).

    Article  CAS  Google Scholar 

  17. Feher, V.A., Baldwin, E.P. & Dahlquist, F.W. Nature Struct. Biol. 3, 516–521 (1996).

    Article  CAS  Google Scholar 

  18. Daragan, V.A. & Mayo, K.H. Prog. Nucl. Magn. Reson. Spectrosc. 31, 63–105 (1997).

    Article  CAS  Google Scholar 

  19. Fischer, M.W.F., Majumdar, A. & Zuiderweg, E.R.P. Prog. Nucl. Magn. Reson. Spectrosc. 33, 207–272 (1998).

    Article  CAS  Google Scholar 

  20. Montelione, G.T. & Wagner, G. J. Am. Chem. Soc. 111, 3096–3098 (1989).

    Article  CAS  Google Scholar 

  21. Farrow, N., Zhang, O., Forman-Kay, J.D. & Kay L.E. J. Biomol. NMR 4, 727–734 (1994).

    Article  CAS  Google Scholar 

  22. Wider, G., Neri, D. & Wuthrich, K. J. Biomol. NMR 1, 93–98 (1991).

    Article  CAS  Google Scholar 

  23. Rao, B.D.N. Methods Enzymol. 176, 279–311 (1989).

    Article  CAS  Google Scholar 

  24. Akke, M. & Palmer, A.G. J. Am. Chem Soc. 118, 911–912 (1996).

    Article  CAS  Google Scholar 

  25. Zinn-Justin, S., Berthault, P., Guenneugues, M. & Desvaux, H. J. Biomol. NRM 10, 363–372 (1997).

    Article  CAS  Google Scholar 

  26. Loria, J. P., Rance, M. & Palmer, A.G. J. Am. Chem. Soc., 121, 2331–2332 (1999).

    Article  CAS  Google Scholar 

  27. Skrynnikov, N.R., Mulder, F.A.A., Hon, B., Dahlquist, F. & Kay, L.E. J. Am. Chem. Soc. 123, 4556–4566 (2001).

    Article  CAS  Google Scholar 

  28. Mulder, F.A.A., Hon, B., Muhandiram, D.R., Dahlquist, F.W. & Kay, L.E. Biochemistry 39, 12614–12622 (2000).

    Article  CAS  Google Scholar 

  29. Ishima, R., Louis, J. & Torchia, D.A. J. Am. Chem. Soc. 121, 11589–11590 (1999).

    Article  CAS  Google Scholar 

  30. Goto, N.K., Skrynnikov, N.R., Dahlquist, F.W. & Kay, L.E. J. Mol. Biol. 308, 745–764 (2001).

    Article  CAS  Google Scholar 

  31. Vugmeyster, L., Kroenke, C.D., Picart, F., Palmer III, A.G. & Raleigh, D.P. J. Am. Chem. Soc. 122, 5387–5388 (2000).

    Article  CAS  Google Scholar 

  32. Olejniczak, E.T., Zhou, M-M. & Fesik, S.W. Biochemistry 36, 4118–4224 (1997).

    Article  CAS  Google Scholar 

  33. Judd, D.A. et al. J. Am. Chem. Soc. 123, 886–897 (2001).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors would like to thank B. Matthews and C. Hill for kindly allowing us to use their figures for illustrative purposes and the appropriate journals for permission to reproduce them, and Mark Rance for a fruitful discussion.

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Authors and Affiliations

  1. the Department of Molecular & Structural Biochemistry, North Carolina State University, Raleigh, 27695, North Carolina, USA

    John Cavanagh

  2. the Duke University NMR Center, Durham, 27710, North Carolina, USA

    Ronald A. Venters

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  1. John Cavanagh
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  2. Ronald A. Venters
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Correspondence to John Cavanagh or Ronald A. Venters.

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Cavanagh, J., Venters, R. Protein dynamic studies move to a new time slot. Nat Struct Mol Biol 8, 912–914 (2001). https://doi.org/10.1038/nsb1101-912

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