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Structure of a conserved RNA component of the peptidyl transferase centre

The structure of a conserved hairpin loop involved in peptidyl–tRNA recognition by SOS ribosomal subunits has been solved by NMR. The loop is closed by a novel G–C base pair and presents guanine residues for RNA recognition.

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References

  1. Noller, H.F. Annu. Rev. Biochem. 60, 191–227 (1991).

    Article  CAS  Google Scholar 

  2. Lieberman, K.R. & Dahlberg, A.E. J. Biol. Chem. 269, 16163–16169 (1994).

    CAS  PubMed  Google Scholar 

  3. Samaha, R.R., Green, R. & Noller, H.F. Nature 377, 309–314 (1995).

    Article  CAS  Google Scholar 

  4. Moazed, D. & Noller, H.F. Cell 57, 585–597 (1989).

    Article  CAS  Google Scholar 

  5. Green, R., Samaha, R.R. & Noller, H.F. J. Mol. Biol. 266, 40–50 (1997).

    Article  CAS  Google Scholar 

  6. Moazed, D. & Noller, H.F. Proc. Natl Acad. Sci. USA. 88, 3725–3728 (1991).

    Article  CAS  Google Scholar 

  7. Allain, F.H.-T. & Varani, G. J. Mol. Biol. 250, 333–353 (1995).

    Article  CAS  Google Scholar 

  8. Heus, H.A. & Pardi, A. Science 253, 191–194 (1991).

    Article  CAS  Google Scholar 

  9. Szewczak, A.A. & Moore, P.B. J. Mol. Biol. 247, 81–98 (1995).

    Article  CAS  Google Scholar 

  10. Gutell, R.R., Gray, M.W. & Schnare, M.N. Nucleic Acids Research 21, 3055–3074 (1993).

    Article  CAS  Google Scholar 

  11. Saenger, W. Principles of Nucleic Acid Structure (Springer-Verlag, Berlin, Germany; 1984).

    Book  Google Scholar 

  12. Cate, J.H., et al. Science 273, 1678–1685 (1996).

    Article  CAS  Google Scholar 

  13. Sirum-Connolly, K. & Mason, T.L. Science 262, 1886–1889 (1993).

    Article  CAS  Google Scholar 

  14. Green, R. & Noller, H.F. RNA 2, 1011–1021 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Joseph, S. & Noller, H.F. EMBO J. 15, 910–916 (1996).

    Article  CAS  Google Scholar 

  16. Puglisi, J.D. & Wyatt, J.R. Meth. Enz. 261, 323–350 (1995).

    Article  CAS  Google Scholar 

  17. Puglisi, J.D., Tan, R., Calnan, B.J., Frankel, A.D. & Williamson, J.R. Science 257, 76–80 (1992).

    Article  CAS  Google Scholar 

  18. Santoro, J. & King, G.J. Mag. Res. 97, 202–207 (1992).

    CAS  Google Scholar 

  19. Marino, J.P. et al. J. Am. Chem. Soc. 116, 6472–6473 (1994).

    Article  CAS  Google Scholar 

  20. Sklénar, V., Miyashiro, H., Zon, G. & Bax, A. FEBS Letters 208, 94–98 (1986).

    Article  Google Scholar 

  21. Sklenar, V., Dieckmann, T., Butcher, S.E. & Feigon, J. J. Biomol. NMR 7, 83–87 (1996).

    Article  CAS  Google Scholar 

  22. Simorre, J.P., Zimmermann, G.R., Pardi, A., Farmer, B.T.I. & Mueller, L. J. Biomol. NMR 6, 427–432 (1995).

    Article  CAS  Google Scholar 

  23. Simorre, J., Zimmermann, G.R., Mueller, L. & Pardi, A. J. Biomol. NMR 7, 153–156 (1996).

    Article  CAS  Google Scholar 

  24. Simorre, J.P., Zimmermann, G.R., Mueller, L. & Pardi, A. J. Am. Chem. Soc. 118, 5316–5317 (1996).

    Article  CAS  Google Scholar 

  25. Vuister, G.W. et al. J. Mag. Res. Ser. B 101, 210–213 (1993).

    Article  CAS  Google Scholar 

  26. Mueller, L., Legault, P. & Pardi, A. J. A. Chem. Soc 117, 11043–11048 (1995).

    Article  CAS  Google Scholar 

  27. Fourmy, D., Recht, M., Blanchard, S.D. & Puglisi, J.D. Science 274, 1367–1371 (1996).

    Article  CAS  Google Scholar 

  28. Kraulis, P.J. Appl. Crystallogr. 24, 946–950 (1991).

    Article  Google Scholar 

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Correspondence to Joseph D. Puglisi.

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Viani Puglisi, E., Green, R., Noller, H. et al. Structure of a conserved RNA component of the peptidyl transferase centre. Nat Struct Mol Biol 4, 775–778 (1997). https://doi.org/10.1038/nsb1097-775

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