What prevents the replisome complex from moving along the DNA or breaking down when the replication fork stalls or encounters a DNA lesion? A recent paper describes how checkpoint proteins, Mrc1 and Tof1 couple the replisome to DNA synthesis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Tercero, J.A., Longhese, M.P. & Diffley, J.F.X. Mol. Cell 11, 1323–1336 (2003).
Katou, Y. et al. Nature 424, 1078–1083 (2003).
Nyberg, K.A., Michelson, R.J., Putnam, C.W. & Weinert, T.A. Annu. Rev. Genet. 36, 617–56 (2002).
Diffley, J.F.X. et al. Cold Spring Harbor Symp. Quant. Biol. 65, 333–342 (2000).
Osborn, A.J. & Elledge, S.J. Genes Dev. 17, 1755–1767 (2003).
Alcasabas, A.A. et al. Nat. Cell Biol. 3, 958–965 (2001).
Cobb, J.A., Bjergbaek, L., Shimada, K., Frei, C. & Gasser, S.M. EMBO J. 22, 4325–4336 (2003).
Foss, E.J. Genetics 157, 567–577 (2001).
Lee, J., Kumagai, A. & Dunphy, W.G. Mol. Cell 11, 329–340 (2003).
Dalgaard, J.Z. & Klar, A.J. Cell 102, 745–751 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zegerman, P., Diffley, J. Lessons in how to hold a fork. Nat Struct Mol Biol 10, 778–779 (2003). https://doi.org/10.1038/nsb1003-778
Issue Date:
DOI: https://doi.org/10.1038/nsb1003-778
This article is cited by
-
Mrc1, a non-essential DNA replication protein, is required for telomere end protection following loss of capping by Cdc13, Yku or telomerase
Molecular Genetics and Genomics (2007)
