Abstract
The mammalian X-ray cross-complementing group 1 protein (XRCC1) is an important player in base excision repair of damaged DNA. Two new findings help to elucidate its role — biochemical data suggest that this multidomain protein interacts not only with three different enzymes, but also with the nicked DNA itself, and NMR data reveal the structure of the domain that interacts with both DNA polymerase β and DNA.
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References
Wood, R.D. Annu. Rev. Biochem. 65, 135–167 (1996).
Sancar, A. Annu. Rev. Biochem. 65, 43–81 (1996).
Parikh, S.S., Mol, C.D., Hosfield, D.J & Tainer, J.A. Curr Opin Struct Biol. 9, 37–47 (1999).
Wilson, S.H. Mutat. Res. 407, 203–215 (1998).
Caldecott, K.W., McKeown, C.K. Tucker, J.D., Ljungquist S. & Thompson, L.H. Mol. Cell. Biol. 14, 68–76 (1994).
Caldecott, K.W., Aoufouchi, S., Johnson, P. and Shall, S. Nucleic Acids Res. 24, 4387–4394 (1996).
Masson, M. et al. Mol. Cell. Biol. 18, 3563– 3571 (1998).
Marintchev, A. et al. Nature Struct. Biol. 7, 884– 893 (1999).
Sawaya, M.R., Prasad, R., Wilson, S.H., Kraut, J. & Pelletier, H. Biochemistry, 36, 11205– 11215 (1997).
Parikh, S.S. et al. EMBO J. 17, 5214–5226 (1998).
Bharati, S., Krokan, H.E., Kristiansen, L., Otterlei, M. & Slupphaug, G. Nucleic Acids Res. 26, 4953–4959 (1998).
Bennett, R.A., Wilson, 3rd, D.M., Wong, D. & Demple, B. Proc. Natl. Acad. Sci. USA. 94, 7166– 7169 (1997).
Nash, R.A., Caldecott, K.W., Barnes, D.E. & Lindahl, T. Biochemistry, 36, 5207–5211 (1997).
Callebaut, I. & Mornon, J.P. FEBS Lett. 400, 25–30 (1997).
Bork, P. et al. FASEB J. 11, 68–76 (1997).
Zhang, X. et al. EMBO J. 17, 6404–6411 (1998).
Wei, Y.F. et al. Mol. Cell. Biol. 1995. 15, 3206–3216 (1995).
Molinete, M. et al. EMBO J. 12, 2109–2117 (1993).
Chatterjee, S., Berger, S.J. & Berger, N.A. Mol. Cell. Biochem. 1999. 193, 23–30 (1999).
Althaus, F.R. et al. Mol. Cell. Biochem. 193, 5– 11 (1999).
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Rice, P. Holding damaged DNA together. Nat Struct Mol Biol 6, 805–806 (1999). https://doi.org/10.1038/12257
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DOI: https://doi.org/10.1038/12257
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