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The solution structure of the first KH domain of FMR1, the protein responsible for the fragile X syndrome

Nature Structural Biologyvolume 4pages712716 (1997) | Download Citation

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  • A Corrigendum to this article was published on 01 October 1997

The structure and dynamics of the first KH domain of FMR1 — the protein responsible for fragile X syndrome — reveal that an exposed loop is highly flexible despite containing a GxxG motif that is well conserved throughout the KH family. We suggest that this region provides a putative binding surface for RNA recognition.

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Affiliations

  1. EMBL, Meyerhofstr. 1, D-69012, Heidelberg, Germany

    • Giovanna Musco
    • , Abdelhakim Kharrat
    • , Gunter Stier
    • , Franca Fraternali
    • , Toby J. Gibson
    •  & Michael Nilges
  2. IRCOF, Universite de Rouen, 76821, Mont-Saint-Aignan, Cedex, France

    • Annalisa Pastore

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Correspondence to Giovanna Musco.

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https://doi.org/10.1038/nsb0997-712

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