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Crystal structure of the molybdate binding protein ModA


The specificity exhibited by the molybdate binding protein ModA for molybdate and tungstate reflects the size and ligands of the anion binding pocket.

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  1. Rech, S., Deppenmeier, U. & Gunsalus, R.P. J. Bacteriol. 177, 1023–1029 (1995).

    Article  CAS  Google Scholar 

  2. Quiocho, F.A. Curr. Opin. Struct. Biol. 1, 922–933 (1991).

    Article  CAS  Google Scholar 

  3. Quiocho, F.A. Phil. Tram. Koy. Soc. Lond. B B326, 341–352 (1990).

    Article  Google Scholar 

  4. Williams, R.J.P. in Molybdenum: an outline of its chemistry and uses (eds. Braithwaite, E.R. & Haber, J.) 419–451 (Elsevier, Amsterdam; 1994).

    Book  Google Scholar 

  5. Pflugrath, J.W. & Quiocho, F.A. J. Mol. Biol. 200, 163–180 (1988).

    Article  CAS  Google Scholar 

  6. Rech, S., Wolin, C. & Gunsalus, R.P. J. Biol. Chem. 271, 2557–2562 (1996).

    Article  CAS  Google Scholar 

  7. Jacobson, B.L. & Quiocho, F.A. J. Mol. Biol. 204, 783–787 (1988).

    Article  CAS  Google Scholar 

  8. Pardee, A.B. J. Biol. Chem. 241, 5886–5892 (1966).

    CAS  PubMed  Google Scholar 

  9. Luecke, H. & Quiocho, F.A. Nature 347, 402–406 (1990).

    Article  CAS  Google Scholar 

  10. Luque, F., Mitchenall, LA., Chapman, M., Christine, R. & Pau, R.N. Mole. Microbiol. 7, 447–459 (1993).

    Article  CAS  Google Scholar 

  11. Wang, G., Angermuller, S. & Klipp, W. J. Bacteriol. 175, 3031–3042 (1993).

    Article  CAS  Google Scholar 

  12. Tytko, K.-H. & Trobisch, U. in Gmelin Handbook of Inorganic Chemistry: Molybdenum Supplement Volume B 3a (eds. Katscher, H. & Schröder, F.) 317 (Springer-Verlag, Berlin; 1987).

    Google Scholar 

  13. Gatehouse, B.M. & Leverett, P. J. Chem. Soc. 849–854 (1969).

  14. Koster, A.S., Kools, F.X.N.M. & Rieck, G.D. Acta Crystallogr. B25, 1704–1708 (1969).

    Article  Google Scholar 

  15. Baur, W. Acta Crystallogr. 17, 1361–1369 (1964).

    Article  CAS  Google Scholar 

  16. Kleywegt, G.J. & Jones, T.A. Acta Crystallogr. D50, 178–185 (1994).

    CAS  Google Scholar 

  17. Hubbard, S.J. & Argos, P. Protein Engng. 8, 1011–1015 (1995).

    Article  CAS  Google Scholar 

  18. Caminiti, R., Paschina, G., Pinna, G. & Magini, M. Chem. Phys. Lett. 64, 391–395 (1979).

    Article  CAS  Google Scholar 

  19. Johansson, G. & Caminiti, R.Z Naturforsch. A41, 1325–1329 (1986).

    Google Scholar 

  20. He, J.J. & Quiocho, F.A. Science 251, 1479–1481 (1991).

    Article  CAS  Google Scholar 

  21. Shan, S.O., Loh, S. & Herschlag, D. Science 272, 97–101 (1996).

    Article  CAS  Google Scholar 

  22. Bourne, E.J., Hutson, D.H. & Weigel, H. J. Chem. Soc. 35–38 (1961).

  23. Schilde, U. & Uhlemann, E. Reactive Polym. 20, 181–188 (1993).

    Article  CAS  Google Scholar 

  24. Ledvina, P.S., Yao, N.H., Choudhary, A. & Quiocho, F.A. Proc. Natl Acad. Sci. U.S.A. 93, 6786–6791 (1996).

    Article  CAS  Google Scholar 

  25. Lawson, D.M., Williams, C.E., White, D.J., Choay, A.P., Mitchenall, L.A. and Pau Dalton Trans, R.N. Pau Dalton Trans. 21, in the press (1997).

    Google Scholar 

  26. Otwinowski, Z. & Minor, W. Meth. Enz. 276, 307–326 (1997).

    Article  CAS  Google Scholar 

  27. Otwinowski, Z. in Isomorphous Replacement and Anomalous Scattering: Proceedings of the CCP4 Study Weekend (eds. Wolf, W., Evans, P.R. & Leslie, A.G.W.) 80–86 (SERC Daresbury Laboratory.UK; 1991).

    Google Scholar 

  28. Abrahams, J.P. & Leslie, A.G.W. Acta Crystallogr. D52, 30–42 (1996).

    CAS  Google Scholar 

  29. Jones, T.A., Zou, J.Y., Cowan, S.W. & Kjeldgaard, M. Acta Crystallogr. A47, 110–119 (1991).

    Article  CAS  Google Scholar 

  30. Bruünger, A.T., Kuriyan, J. & Karplus, M. Science 235, 458–460 (1987).

    Article  Google Scholar 

  31. Engh, R.A. & Huber, R. Acta Crystallogr. A47, 392–400 (1991).

    Article  CAS  Google Scholar 

  32. Laskowski, R.A., MacArthur, M.W., Moss, D.S. & Thornton, J.M. J.Appl. Crystallogr. 26, 283–291 (1993).

    Article  CAS  Google Scholar 

  33. Kraulis, P.J. J.Appl. Crystallogr. 24, 946–950 (1991).

    Article  Google Scholar 

  34. Bacon, D. & Anderson, W.F. J. Mole. Graph. 6, 219–220 (1988).

    Article  Google Scholar 

  35. Merritt, E.A. & Murphy, M.E.P. Acta Crystallogr. D50, 869–873 (1994).

    CAS  Google Scholar 

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Correspondence to Douglas C. Rees.

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Hu, Y., Rech, S., Gunsalus, R. et al. Crystal structure of the molybdate binding protein ModA. Nat Struct Mol Biol 4, 703–707 (1997).

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