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Crystal structure of RhoA–GDP and its functional implications

Nature Structural Biology volume 4, pages 699703 (1997) | Download Citation

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RhoA, a ubiquitous intracellular GTPase, mediates cytoskeletal responses to extracellular signals. A 2.1 Å resolution crystal structure of the human RhoA–GDP complex shows unique stereochemistry in the switch I region, which results in a novel mode of Mg2+ binding.

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Affiliations

  1. Department of Molecular Physiology and Biological Physics, Center for Structural Biology, University of Virginia Health Sciences Center, P.O. Box 10011 Charlottesville, Virginia 22906-0011, USA.

    • Yunyi Wei
    • , Yan Zhang
    • , Urszula Derewenda
    • , Xiaopu Liu
    • , Wladek Minor
    • , Robert K. Nakamoto
    • , Avril V. Somlyo
    • , Andrew P. Somlyo
    •  & Zygmunt S. Derewenda
  2. email: zsd4n@virginia.edu

    • Zygmunt S. Derewenda

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https://doi.org/10.1038/nsb0997-699

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