Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

A catalytic DNA for porphyrin metallation

A guanine-rich DNA oligomer (33 nucleotides), isolated by in vitro selection from a random-sequence DNA library, catalyses the insertion of copper(II) and zinc ions into mesoporphyrin IX.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Kruger, K. et al. Cell 31, 147–157 (1982).

    Article  CAS  Google Scholar 

  2. Guerrier-Takada, K., Gardiner, T., Marsh, N., Pace, N. & Altman, S. Cell 35, 849–857 (1983).

    Article  CAS  Google Scholar 

  3. White, H.B. III J. Mol. Evol. 7, 101–104 (1976).

    Article  CAS  Google Scholar 

  4. Gilbert, W. Nature 319, 618 (1986).

    Article  Google Scholar 

  5. Benner, S.A., Ellington, A.D. & Traver, A. Proc. Natl. Acad. Sci. USA 86, 7054–7058 (1989).

    Article  CAS  Google Scholar 

  6. Gesteland, R.F. & Atkins, J.F. (eds.) The RNA World: The Nature of Modern RNA Suggests a Prebiotic RNA World (Cold Spring Harbor Laboratory Press, 1993).

    Google Scholar 

  7. Cochran, A.G. & Schultz, P.G. Science 249, 781–783 (1990).

    Article  CAS  Google Scholar 

  8. Ellington, A.D. & Szostak, J.W. Nature 346, 818–822 (1990).

    Article  CAS  Google Scholar 

  9. Tuerk, C. & Gold, L. Science 249, 505–510 (1990).

    Article  CAS  Google Scholar 

  10. Ellington, A.D. & Szostak, J.W. Nature 355, 850–852 (1992).

    Article  CAS  Google Scholar 

  11. Pauling, L. Am. Sci. 36, 51 (1948).

    CAS  PubMed  Google Scholar 

  12. Jencks, W.P. Catalysis in Chemistry and Enzymology (McGraw-Hill, New York, 1969).

    Google Scholar 

  13. Schultz, P.G. & Lerner, R.A. Science 269, 1835–1842 (1995).

    Article  CAS  Google Scholar 

  14. Dailey, H.A. & Fleming, J.E. J. Biol. Chem. 11, 453 (1983).

    Google Scholar 

  15. Li, Y., Geyer, C.R. & Sen, D. Biochemistry 35, 6911–6922 (1996).

    Article  CAS  Google Scholar 

  16. Gellert, M., Lipsett, M.N. & Davies, D.R. Proc. Natl. Acad. Sci. USA 48, 2013–2018 (1962).

    Article  CAS  Google Scholar 

  17. Pinnavaia, T.J. et al. J. Am. Chem. Soc. 100, 3625–3627 (1978).

    Article  CAS  Google Scholar 

  18. Sundquist, W.I. & Klug, A. Nature 342, 825–829 (1989).

    Article  CAS  Google Scholar 

  19. Williamson, J.R., Raghuraman, M.K. & Cech, T.R. Cell 59, 871–880 (1989).

    Article  CAS  Google Scholar 

  20. Sen, D. & Gilbert, W. Nature 344, 410–414 (1990).

    Article  CAS  Google Scholar 

  21. Kazakov, S.A., Astashkins, T.G., Mamaev, S.V. & Vlassov, V.V. Nature 335, 186–188 (1988).

    Article  CAS  Google Scholar 

  22. Breaker, R.R. & Joyce, G.F. Chem. Biol. 1, 23–229 (1994).

    Article  Google Scholar 

  23. Cuenoud, B. & Szostak, J.W. Nature 375, 611–614 (1995).

    Article  CAS  Google Scholar 

  24. Breaker, R.R. & Joyce, G.F. Chem Biol. 2, 655–660 (1995).

    Article  CAS  Google Scholar 

  25. Lorsch, J.R. & Szostak, J.W. Acc. Chem. Res. 29, 103–110 (1996).

    Article  CAS  Google Scholar 

  26. Joyce, G.F. Current Opin. in Struc. Biol. 4, 331–336 (1994).

    Article  CAS  Google Scholar 

  27. Prudent, J.R., Uno, T. & Schultz, P.G. Science 264, 1924–1927 (1994).

    Article  CAS  Google Scholar 

  28. Morris, K.N. et al. Proc. Natl. Acad. Sci. USA 91, 13028–13032 (1994).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Li, Y., Sen, D. A catalytic DNA for porphyrin metallation. Nat Struct Mol Biol 3, 743–747 (1996). https://doi.org/10.1038/nsb0996-743

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsb0996-743

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing