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SAM breaks its stereotype

Nature Structural & Molecular Biology volume 10, pages 677–679 (2003)Cite this article

Don't prejudge the function of a domain based on its sequence. Two recent studies drive home this message and add the sterile-α motif (SAM) to the growing list of domains that are able to interact with both proteins and nucleic acids.

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Figure 1: Mutational analysis maps a RNA-binding surface of Smg protein.
Figure 2: Protein modules that function as either RNA-binding or protein-interaction domains.

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  1. National Institute of Environmental Health Sciences, Laboratory of Structural Biology, National Institutes of Health, Research Triangle Park, 27709, North Carolina, USA

    Traci M Tanaka Hall

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  1. Traci M Tanaka Hall
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Hall, T. SAM breaks its stereotype. Nat Struct Mol Biol 10, 677–679 (2003). https://doi.org/10.1038/nsb0903-677

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