A recent study of cytomegalovirus assemblin proteinase suggests that dimer-induced stabilization of the oxyanion hole may activate the enzyme.
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Gibson, W. Action at the assemblin dimer interface. Nat Struct Mol Biol 8, 739–741 (2001). https://doi.org/10.1038/nsb0901-739
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DOI: https://doi.org/10.1038/nsb0901-739