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The lysozyme mechanism sorted — after 50 years

Unambiguous evidence for a glycosyl-enzyme intermediate on the lysozyme reaction pathway has recently been reported, finally settling what kind of mechanism this textbook enzyme uses.

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Figure 1: The reaction catalyzed by lysozyme.
Figure 2: Structures of the glycosyl-enzyme intermediates discussed in the text.

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Kirby, A. The lysozyme mechanism sorted — after 50 years. Nat Struct Mol Biol 8, 737–739 (2001). https://doi.org/10.1038/nsb0901-737

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