News & Views | Published:

How to make a metalloprotein

Nature Structural Biology volume 8, pages 733734 (2001) | Download Citation

Subjects

Copper is an essential transition metal that plays a fundamental role in the biochemistry of all aerobic organisms. Recent work elucidating the structural mechanisms of copper delivery to superoxide dismutase provides insight into the cell biology of copper metabolism and serves as an example of how to understand the principles governing the incorporation of metals into proteins.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Lane medical lectures (Stanford University Press, Stanford; 1952).

  2. 2.

    , , & Nature Struct. Biol. 8, 750–754 (2001).

  3. 3.

    & in Molecular and metabolic basis of inherited disease (eds Scriver, C.R., Beaudet, A.L., Sly, W. & Valle, D.) 3105–3126 (McGraw-Hill Publishing, New York; 2001).

  4. 4.

    & J. Biol. Chem. 275,25057–25060 (2000).

  5. 5.

    , , , & Science 284,805–808 (1999).

  6. 6.

    & Science 292, 2488–2492 (2001).

  7. 7.

    Annu. Rev. Biochem. 64, 97–112 (1995).

  8. 8.

    Proc. Natl. Acad. Sci. 97, 2886–2891 (2000).

  9. 9.

    et al. Nature Struct. Biol. 6, 724–729 (1999).

  10. 10.

    et al. Biochemistry 39, 1589–1595 (2000).

  11. 11.

    , & J. Biol. Chem. 273, 23625–23628 (1998).

  12. 12.

    et al. J. Biol. Chem. 274, 23719–23725 (1999).

  13. 13.

    , & J. Biol. Chem. 275, 33771–33776 (2000).

  14. 14.

    et al. Biochemistry 39, 14720–14727 (2000).

  15. 15.

    , , & J. Biol. Chem. 276, in the press (2001).

Download references

Author information

Affiliations

  1. Thomas B. Bartnikas and Jonathan D. Gitlin are in the Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

    • Thomas B. Bartnikas
    •  & Jonathan D. Gitlin

Authors

  1. Search for Thomas B. Bartnikas in:

  2. Search for Jonathan D. Gitlin in:

Corresponding author

Correspondence to Jonathan D. Gitlin.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nsb0901-733

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing