News & Views | Published:

The C-terminus of p53: the more you learn the less you know

Nature Structural Biology volume 8, pages 730732 (2001) | Download Citation

Subjects

NMR analyses of variants of the p53 tumor suppressor protein that either contain or lack the C-terminus reveal that the C-terminus neither interacts with other regions of p53 nor has an impact on the conformation of the rest of the molecule. Nevertheless, the C-terminus is likely to be critical for regulation of p53 function.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    & Cell Mol. Life Sci. 55, 76–87 (1999).

  2. 2.

    & EMBO J. 12, 5057–5064 (1993).

  3. 3.

    & Curr. Biol. 4, 865–875 (1994).

  4. 4.

    , , , & Mol. Cell. Biol. 17, 6255–6264 (1997).

  5. 5.

    et al. Nature Struct. Biol. 8, 756–760 (2001).

  6. 6.

    , , & Cell 71, 875–886 (1992).

  7. 7.

    & Pathol. Biol. 48, 227–245 (2000).

  8. 8.

    , , & Nucleic Acids Res. 21, 3167–31374 (1993).

  9. 9.

    , , & Cancer Res. 55, 3490–3494 (1995).

  10. 10.

    , & Cell 83, 237–245 (1995).

  11. 11.

    et al. Oncogen 13, 2477–2482 (1996).

  12. 12.

    et al. Nature Med. 3, 632–638 (1997).

  13. 13.

    et al. J. Biol. Chem. 274, 34924–34931 (1999).

  14. 14.

    , & Proc. Natl. Acad. Sci. USA 95, 6079–6084 (1998).

  15. 15.

    et al. Genes Dev. 11, 558–570 (1997).

  16. 16.

    , , & Nature Genet. 19, 175–178. (1998).

  17. 17.

    et al. Oncogene 16, 1713–1721 (1998).

  18. 18.

    et al. J. Biol. Chem. 275, 34122–34130 (2000).

  19. 19.

    , & Proc. Natl. Acad. Sci. USA 92, 5729–5733 (1995).

  20. 20.

    , , & Proc. Natl. Acad. Sci. USA 94, 12366–12371 (1997).

  21. 21.

    , , & J. Biol. Chem. 275, 39944–39953 (2000).

  22. 22.

    & Mol. Cell 8, 57–69 (2001).

  23. 23.

    , & Oncogene 11, 337–349 (1995).

  24. 24.

    , , & Proc. Natl. Acad. Sci. USA 94, 8982–8987 (1997).

  25. 25.

    , , & Genes Dev. 10, 2438–2451 (1996).

  26. 26.

    et al. Oncogene 9, 3249–3257 (1994).

  27. 27.

    , , , & Oncogene 10, 789–793 (1995).

  28. 28.

    , & Mol. Cell. Biol. 19, 1751–1758 (1999).

  29. 29.

    , & Oncogene 19, 3395–3403 (2000).

  30. 30.

    et al. Biochemistry 36, 10117–10124 (1997).

  31. 31.

    et al. EMBO J. 18, 1660–1672 (1999).

  32. 32.

    , , , & Mol. Cell. Biol. 20, 8458–8467 (2000).

Download references

Author information

Affiliations

  1. Jinwoo Ahn and Carol Prives are in the Department of Biological Sciences, Columbia University, New York, New York 10027, USA.

    • Jinwoo Ahn
    •  & Carol Prives

Authors

  1. Search for Jinwoo Ahn in:

  2. Search for Carol Prives in:

Corresponding author

Correspondence to Carol Prives.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nsb0901-730

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing