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Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation

Nature Structural Biology volume 4, pages 601–604 (1997)Cite this article

Structural comparison of thymidylate kinase complexed with either dTMP or with AZTMP suggests that the low phosphorylation rate of AZTMP is due to an induced P-loop movement.

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Authors and Affiliations

  1. Max Planck Institute for Molecular Physiology, Department of Structural Biology, Rheinlanddamm 201, 44139, Dortmund, Germany

    Arnon Lavie, Roger S. Goody, Jochen Reinstein & Ilme Schlichting

  2. Max Planck Institute for Molecular Physiology, Department of Structural Biology, Rheinlanddamm 201, 44139, Dortmund, Germany

    Ingrid R. Vetter

  3. Max Planck Institute for Biophysical Chemistry, Department of Molecular Genetics, 37018, Gottingen, Germany

    Manfred Konrad

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  1. Arnon Lavie
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  2. Ingrid R. Vetter
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  6. Ilme Schlichting
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Lavie, A., Vetter, I., Konrad, M. et al. Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation. Nat Struct Mol Biol 4, 601–604 (1997). https://doi.org/10.1038/nsb0897-601

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