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Pulling the calcium trigger

The structure of the calcium-bound core of human cardiac troponin reveals distinct subdomains connected by flexible linkers, implying that domain reorientation motions within the complex trigger muscle contraction.

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Figure 1: Orientations of the protein components of the thin filament in the relaxed and contracted states.
Figure 2: Troponin complexes.

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Acknowledgements

The author thanks D. Lindhout for help with the model and figures and M. Li and T. Blumenschein for valuable discussions.

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Sykes, B. Pulling the calcium trigger. Nat Struct Mol Biol 10, 588–589 (2003). https://doi.org/10.1038/nsb0803-588

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