Unfolded, yes, but random? Never!

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NMR experiments with partially aligned protein molecules in strongly denaturing conditions suggest that the unfolded state is less chaotic than is widely believed. Hence protein folding is probably less paradoxical than Levinthal originally thought.

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Plaxco, K., Gross, M. Unfolded, yes, but random? Never!. Nat Struct Mol Biol 8, 659–660 (2001) doi:10.1038/90349

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