The membrane-inserted structure of a synthetic fusion peptide of influenza virus hemagglutinin has been determined. Structures such as this will further our understanding of the roles of the fusion peptide and may provide a means to develop a systematic view for how fusion peptide mutations in hemagglutinin affect the membrane fusion process.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hernandez, L.D., Hoffman, L.R., Wolfsberg, T.G. & White, J.M. Annu. Rev. Cell Dev. Biol. 12, 627–661 (1996).
Durrer, P. et al. J. Biol. Chem. 271, 13417–13421 (1996).
Durell, S.R., Martin, I., Ruysschaert, J.M., Shai, Y. & Blumenthal, R. Mol. Membr. Biol. 14, 97–112 (1997).
Han, X., Bushweller, J.H., Cafiso, D.S. & Tamm, L.K. Nature Struct. Biol. 8 715–720 (2001).
Wilson, I.A., Skehel, J.J. & Wiley, D.C. Nature 289, 366–373 (1981).
Chen, J., Skehel, J.J. & Wiley, D.C. Proc. Natl. Acad. Sci. USA 96, 8967–8972 (1999).
Bullough, P.A., Hughson, F.M., Skehel, J.J. & Wiley, D.C. Nature 371, 37–43 (1994).
Siegel, D.P. & Epand, R.M. Biochim. Biophys. Acta 1468, 87–98 (2000).
Dubovskii, P.V., Li, H., Takahashi, S., Arseniev, A.S. & Akasaka, K. Protein Sci. 9, 786–798 (2000).
Han, X. & Tamm, L.K. Proc. Natl. Acad. Sci. USA 97, 13097–13102 (2000).
Han, X. & Tamm, L.K. J. Mol. Biol. 304, 953–965 (2000).
Carr, C.M. & Kim, P.S. Cell 73, 823–832 (1993).
Melikyan, G.B. et al. J. Cell Biol. 151, 413–424 (2000).
Markovic, I., Leikina, E., & Chernomordik, LV. Biophys. J. 78, 59A (2000).
White, J.M. & Wilson, I.A. J. Cell Biol. 105, 2887–2896 (1987).
Chernomordik, L.V., Frolov, V.A., Leikina, E., Bronk, P. & Zimmerberg, J. J. Cell Biol. 140, 1369–1382 (1998).
Pritsker, M., Rucker, J., Hoffman, T.L., Doms, R.W. & Shai, Y. Biochemistry 38, 11359–11371 (1999).
Qiao, H., Armstrong, R.T., Melikyan, G.B., Cohen, F.S. & White, J.M. Mol. Biol. Cell 10, 2759–2769 (1999).
Schoch, C. & Blumenthal, R. J. Biol. Chem. 268, 9267–9274 (1993).
Steinhauer, D.A., Wharton, S.A., Skehel, J.J. & Wiley, D.C. J. Virol. 69, 6643–6651 (1995).
Gething, M.J., Doms, R.W., York, D. & White, J. J. Cell Biol. 102, 11–23 (1986).
Jin, H., Leser, G.P. & Lamb, R.A. EMBO J. 13, 5504–5515 (1994).
Kuzmin, P.I., Zimmerberg, J., Chizmadzhev, Y.A. & Cohen, F.S. Proc. Natl. Acad. Sci. USA 98, 7235–7240 (2001).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Cohen, F., Melikyan, G. Implications of a fusion peptide structure. Nat Struct Mol Biol 8, 653–655 (2001). https://doi.org/10.1038/90341
Issue Date:
DOI: https://doi.org/10.1038/90341
