Defining polyubiquitin chain topology

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Recent crystal structures suggest models for how an asymmetric E2/E2-like protein complex synthesizes a polyubiquitin chain that functions in DNA repair and NF-κB activation pathways.

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Figure 2: Structure of the Ubc13–Mms2 complex.

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Correspondence to Christopher P. Hill.

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Chan, N., Hill, C. Defining polyubiquitin chain topology. Nat Struct Mol Biol 8, 650–652 (2001) doi:10.1038/90337

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