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Survivin structure: crystal unclear

Nature Structural Biology volume 7, pages 620–623 (2000)Cite this article

Three recent X-ray structures of the anti-apoptotic protein survivin reveal two different dimeric interfaces. More experiments are needed to determine the biologically relevant dimer interface and to probe survivin function on the basis of its structure.

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Figure 1: Structure-based alignment of three BIR domains.
Figure 2: Observed dimeric arrangement of human survivin: the bow-tie model2,3.
Figure 3: Proposed dimeric arrangement of mouse survivin: the zinc chelation model4.

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Acknowledgements

The author thanks J. Noel for communicating unpublished data, J. Noel and O. Dideberg for the atomic coordinates of human survivin and S. Muchmore for help with the preparation of Fig. 3.

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  1. the Department of Molecular Biology, Lewis Thomas Laboratory, Princeton, 08544, New Jersey, USA

    Yigong Shi

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  1. Yigong Shi
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Shi, Y. Survivin structure: crystal unclear. Nat Struct Mol Biol 7, 620–623 (2000). https://doi.org/10.1038/77904

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