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Finding the function buried in SAND

The SAND domain is present in many proteins that have been linked to chromatin-dependent transcriptional regulation and human disease, but their function has remained unknown. Recent studies have revealed that these modules are DNA binding domains of novel molecular structure.

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Figure 1: SAND domain contexts and functions.
Figure 2: Do SAND domains recognize the major groove in a manner reminiscent of the helix-turn-helix proteins?


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J.M.W. and R.T.C. are supported by grants from the National Institutes of Health and Department of Energy.

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Correspondence to Robert T. Clubb.

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Wojciak, J., Clubb, R. Finding the function buried in SAND. Nat Struct Mol Biol 8, 568–570 (2001).

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