Portrait of a P-type pump

The first high resolution structure of an ATP-dependent cation pump of the P-type family — the Ca2+-ATPase from the sarcoplasmic reticulum of rabbit muscle — has now been determined.

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Figure 1: Topology diagram of the nucleotide binding (N, yellow) and phosphorylation (P, red) domains of the Ca2+-ATPase, prepared based on ref. 9.
Figure 2: Schematic diagram of the structure of Ca2+-ATPase, adapted from ref. 9.

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McIntosh, D. Portrait of a P-type pump. Nat Struct Mol Biol 7, 532–535 (2000). https://doi.org/10.1038/76735

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