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Two domains and one RNA: a molecular threesome

Nature Structural Biology volume 6, pages 499–502 (1999)Cite this article

Abstract

Structures of the Drosophila Sex-lethal protein with and without bound RNA reveal an unexpected mode of binding in which tripartite interactions between the two RNA-binding domains and the bound RNA generate specific, high-affinity binding.

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Figure 1: a, apoSxl (ref.1). Dashed lines indicate regions lacking interpretable electron density.

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Acknowledgements

We thank S. Crowder and T. Alber for providing atomic coordinates of apoSxl, and S. Yokoyama for providing atomic coordinates of Sxl–RNA.

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Authors and Affiliations

  1. the Department of Molecular Biology at Princeton University, Princeton, 08544, New Jersey, USA

    Frederick M. Hughson & Paul Schedl

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  1. Frederick M. Hughson
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  2. Paul Schedl
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Correspondence to Frederick M. Hughson or Paul Schedl.

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Hughson, F., Schedl, P. Two domains and one RNA: a molecular threesome. Nat Struct Mol Biol 6, 499–502 (1999). https://doi.org/10.1038/9264

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