News & Views | Published:

Imperfect interfaces

Nature Structural Biologyvolume 5pages412414 (1998) | Download Citation

Subjects

The crystal structure of a T cell receptor bound to a self peptide–major histocompatibility complex antigen reveals poor shape complementarity in the interface between the two proteins, as well as large conformational changes in the T cell receptor combining site upon ligand binding.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Lawrence, M.C. & Colman, P.M. J. Mol. Biol. 234, 946–950 (1993).

  2. 2

    Garcia, K.C. et al. Science 279, 1166–1172 (1998).

  3. 3

    Bentley, G.A., Boulot, G., Karjalainen, K. & Mariuzza, R.A. Science 267, 1984–1987 (1995).

  4. 4

    Fields, B.A. et al. Science 270, 1821–1824 (1995).

  5. 5

    Garcia, K.C. et al. Science 274, 209–219 (1996).

  6. 6

    Garboczi, D.N. et al. Nature 384, 134–141 (1996).

  7. 7

    Housset, D. et al. EMBOJ. 16, 4205–4216 (1997).

  8. 8

    Wang, J. et al. EMBOJ. 17, 10–26 (1998).

  9. 9

    Li, H. et al. Nature 391, 502–506 (1998).

  10. 10

    Jameson, S.C., Hogquist, K.A. & Bevan, M.J. Annu. Rev. Immunol. 13, 93–125 (1995).

  11. 11

    Alam, S.M. et al. Nature 381, 616–620 (1996).

  12. 12

    Bhat et al. Proc. Natl. Acad. Sci. USA 91, 1089–1093 (1994).

  13. 13

    Fields, B.A., Golbbaum, F.A., Ysern, X., Poljak, R.J. & Mariuzza, R.A. Nature 374, 739–742 (1995).

  14. 14

    Corr, M. et al. Science 265, 946–948 (1994).

  15. 15

    Matsui, K., Boniface, J.J., Steffner, P., Reahy, P.A & Davis, M.M. Proc. Natl. Acad. Sci. USA 91, 12862–12866 (1994).

  16. 16

    Valitutti, S., Muller, S., Cella, M., Padovan, E. & Lanzavecchia, A. Nature 375, 148–151 (1995).

  17. 17

    Rabinowitz, J.D., Beeson, C., Lyons, D.S., Davis, M.M. & McConnell, H.M. Proc. Natl. Acad. Sci. USA 93, 1401–1405 (1996).

  18. 18

    Reich, Z. et al. Nature 387, 617–620 (1997).

  19. 19

    Rini, J.M., Schulze-Gahmen, U. & Wilson, I.A. Science 255, 959–965 (1992).

  20. 20

    Stanfield, R.L., Takimoto-Kamimura, M., Rini, J.M., Profy, A.T. & Wilson, I.A. Structure 1, 83 (1993).

  21. 21

    Herron, J.N. et al. Proteins:Struct. Func. Genet. 11, 159–175 (1991).

  22. 22

    Sheriff, S. et al. Proc. Natl. Acad. Sci. USA 84, 8075–8079 (1987).

  23. 23

    Padlan et al. Proc. Natl. Acad Sci. USA 86, 5938–5942 (1989).

  24. 24

    Tulip, W.R., Varghese, J.N., Laver, W.G., Webster, R.G. & Colman, P.M. J. Mol. Biol. 227, 122–148 (1992).

  25. 25

    Atwell, S., Ultsch, M., De Vos, A.M. & Wells, J.A. Science 278, 1125–1128 (1997).

Download references

Author information

Affiliations

  1. the Center for Drug Evaluation and Research, United States Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland, 20857, USA

    • Xavier Ysern
  2. the Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, Maryland, 20850, USA

    • Hongmin Li
    •  & Roy A. Mariuzza

Authors

  1. Search for Xavier Ysern in:

  2. Search for Hongmin Li in:

  3. Search for Roy A. Mariuzza in:

Corresponding author

Correspondence to Roy A. Mariuzza.

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/nsb0698-412

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing