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Structure of coagulation factors IX/X-binding protein, a heterodimer of C-type lectin domains

Coagulation factors IX/X-binding protein is an intertwined dimer with a central loop projecting into the adjoining subunit. Excluding this loop, each subunit has a fold similar to rat mannose-binding protein.

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References

  1. Atoda, H. & Morita, T.J. Biochemistry 106, 808–813 (1989).

    Article  CAS  Google Scholar 

  2. Morita, T., Atoda, H. & Sekiya, F. in Natural Toxins II (eds Singhm, B.R. &Tu, AT.) 187–196 (Plenum Press, New York, NY; 1996).

    Book  Google Scholar 

  3. Drickamer, K. Prog. Nucleic Acid Res. Mol. Biol. 45, 207–232 (1993).

    Article  CAS  Google Scholar 

  4. Weis, W.I. et al. Science 254, 1608–1615 (1991).

    Article  CAS  Google Scholar 

  5. Bertrand, J.A. et al. EMBOJ. 15, 2678–2684 (1996).

    Article  CAS  Google Scholar 

  6. Weis, W.I., Drickamer, K. & Hendrickson, W.A. Nature 360, 127–134 (1992).

    Article  CAS  Google Scholar 

  7. Sekiya, F., Yamashita, T. & Morita, T. Biochemistry 34, 10043–10047 (1995).

    Article  CAS  Google Scholar 

  8. Graves, B.J. et al. Nature 367, 532–538 (1994).

    Article  CAS  Google Scholar 

  9. Mizuno, H., Atoda, H. & Morita, T.J. Mol. Biol. 220, 225–226 (1991).

    Article  CAS  Google Scholar 

  10. Seshadri, T.P. et al. J. Mol. Biol. 220, 481–494 (1991).

    Article  CAS  Google Scholar 

  11. Bennett, M.J., Schlunegger, M.P. & Eisenberg, D. Protein Sci. 4, 2455–2468 (1995).

    Article  CAS  Google Scholar 

  12. Sakabe, N. Nuclear Instr. Methods Physics Res. A303, 448–463 (1991).

    Article  CAS  Google Scholar 

  13. Otwinowski, Z. & Minor, W. in Data Collection and Processing (eds Sawyer, L, Isaacs, N. & Bailery, S.) 556–562 (SERC Daresbury Laboratory, Warrington, 1993).

    Google Scholar 

  14. Collaborative Computational Project, Number 4 Acta Crystallogr. D50, 760–763 (1994).

  15. Otwinowski, Z. in Isomorphous Replacement and Anomalous Scattering (eds. Wolf, W., Evans, P.R. & Leslie, A.G.W.) 80–86 (SERC, Daresbury Laboratory, Daresbury, 1991).

    Google Scholar 

  16. Cowtan, K. A CCP4 Density Modification Package (The CCP4 Suite of Programs, 1994).

  17. Brünger, A.T. X-PLOR (Version 3.1): A System for X-ray Crystallography and NMR (Yale Univ. Press, 1992).

    Google Scholar 

  18. Laskowski, R.A. et al. J. Appl. Crystallogr. 26, 283–291 (1993).

    Article  CAS  Google Scholar 

  19. Kraulis, P.J.J. Appl. Crystallogr. 24, 946–950 (1991).

    Article  Google Scholar 

  20. Nicholls, A.J. GRASP: graphical representation and analysis of surface properties. Columbia University, NY. (1993).

    Google Scholar 

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Mizuno, H., Fujimoto, Z., Koizumi, M. et al. Structure of coagulation factors IX/X-binding protein, a heterodimer of C-type lectin domains. Nat Struct Mol Biol 4, 438–441 (1997). https://doi.org/10.1038/nsb0697-438

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