Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Homing in on intron-encoded endonucleases

Nature Structural Biology volume 4, pages 423–424 (1997)Cite this article

The crystal structure of l-Crel offers the first view of an intron-encoded endonuclease. The structure differs from known endonuclease structures, revealing an elongated saddle shaped molecule ideally suited for binding a long DNA sequence.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Mueller, J.E., Bryk, M., Loizos, N. & Belfort, M. in Nucleates (eds. Linn, S.M., Lloyd, R.S. & Roberts, R.J.) 111–143 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1993).

    Google Scholar 

  2. Heath, P.J., Stephens, K.M., Monnat, R.J. & Stoddard, B.L. Nature Struct. Biol. 468–476 (1997).

  3. Perler, F.B. et al. Nucl. Acids Res. 22, 1125–1127 (1994).

    Article  CAS  Google Scholar 

  4. Aggarwal, A.K. Curr. Opin. Struct. Biol. 5, 11–19 (1995).

    Article  CAS  Google Scholar 

  5. Kim, Y., Geiger, J.H., Hahn, S. & Sigler, P.B. Nature 365, 512–520 (1993).

    Article  CAS  Google Scholar 

  6. Kim, J.L., Nikolov, D.B. & Burley, S.K. Nature 365, 520–527 (1993).

    Article  CAS  Google Scholar 

  7. Endrizzi, J.A., Cronk, J.D., Wang, W., Crabtree, G.R. & Alber, T. Science 268, 556–559 (1995).

    Article  CAS  Google Scholar 

  8. Miller, J., Mclachlan, A.D. & Klug, A. EMBO J. 4, 1609–1614 (1985).

    Article  CAS  Google Scholar 

  9. Henke, R.M., Butow, R.A. & Perlman, P.S. EMBO J. 14, 5094–5099 (1995).

    Article  CAS  Google Scholar 

  10. Gimble, F.S. & Stephens, B.W. J. Biol. Chem. 270, 5849–5856 (1995).

    Article  CAS  Google Scholar 

  11. Anderson, J.E. Curr. Opin. Struct. Biol. 3, 24–30 (1993).

    Article  CAS  Google Scholar 

  12. Newman, M., Strzelecka, T., Dorner, L.F., Schildkraut, I. & Aggarwal, A.K. Nature 368, 660–664 (1994).

    Article  CAS  Google Scholar 

  13. Szczepanek, T. & Lazowska, J. EMBO J. 15, 3758–3767 (1996).

    Article  CAS  Google Scholar 

  14. Mueller, J.E., Smith, D., Bryk, M. & Belfort, M. EMBO J. 14, 5724–5735 (1995).

    Article  CAS  Google Scholar 

  15. Loizos, N., Silva, G.H. & Belfort, M. J. Mol. Biol. 255, 412–424 (1996).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Department of Physiology and Biophysics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York, 10029, USA

    Aneel K. Aggarwal

Authors
  1. Aneel K. Aggarwal
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Aggarwal, A. Homing in on intron-encoded endonucleases. Nat Struct Mol Biol 4, 423–424 (1997). https://doi.org/10.1038/nsb0697-423

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsb0697-423

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing