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The problem with pyrimidines

The chemical properties of cytosine present cells with a serious informational ‘disease’, necessitating enzymes with exquisite specificity for deoxyuridine for its prevention and cure.

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References

  1. Lindahl, T. Nature 362, 709–715 (1993).

    Article  CAS  Google Scholar 

  2. Frederico, L.A., Kunkel, T.A. & Shaw, B.R. Biochemistry 32, 6523–6530 (1993).

    Article  CAS  Google Scholar 

  3. Seeberg, E., Eide, L. & Bjoras, M. Trends Biochem. Sci. 20, 391–397 (1995).

    Article  CAS  Google Scholar 

  4. Savva, R., McAuley-Hecht, K., Brown, T. & Pearl, L.H. Nature 373, 487–493 (1995).

    Article  CAS  Google Scholar 

  5. Larsson, G., Svensson, L.A. & Nyman, P.O. Nature Struct. Biol. 3, 532–538 (1996).

    Article  CAS  Google Scholar 

  6. McGeoch, D. Nucleic Acids Res. 18, 4105–4110 (1990).

    Article  CAS  Google Scholar 

  7. El-Hajj, H.H., Wang, L. & Weiss, B. J. Bacteriol. 174, 4450–4456 (1992).

    Article  CAS  Google Scholar 

  8. Ivarie, R. Nucleic Acids Res. 15, 9975–9983 (1987).

    Article  CAS  Google Scholar 

  9. Ingraham, H.A., Dickey, L. & Goulian, M. Biochemistry 25, 3225–3230 (1986).

    Article  CAS  Google Scholar 

  10. Goulian, M. et al. Adv. Exp. Med. Biol. 195, 89–95 (1986).

    Article  Google Scholar 

  11. El-Hajj, H.H., Zhang, H. & Weiss, B. J. Bacteriol. 170, 1069–1075 (1988).

    Article  CAS  Google Scholar 

  12. Gadsden, M.H., Mclntosh, E.M., Game, J.C., Wilson, P.J. & Haynes, R.H. EMBO J. 12, 4425–4431 (1993).

    Article  CAS  Google Scholar 

  13. Shen,J.C, Rideout,W.M. & Jones,P.A. Nucleic Adds Res. 22, 972–976 (1994).

    Article  CAS  Google Scholar 

  14. Papadopoulos, N. et al. Science 268, 1915–1917 (1995).

    Article  CAS  Google Scholar 

  15. Takahashi, I. & Marmur, J. Nature 197, 794–795 (1963).

    Article  CAS  Google Scholar 

  16. Cone, R., Bonura, T. & Friedberg, E.C. J. Biol. Chem. 255, 10354–10358 (1980).

    CAS  PubMed  Google Scholar 

  17. Savva, R. & Pearl, L.H. Nature Struct. Biol. 2, 752–757 (1995).

    Article  CAS  Google Scholar 

  18. Mol, D.C. et al. Cell 82, 701–708 (1995).

    Article  CAS  Google Scholar 

  19. Price, A.R. & Frato, J. J. Biol. Chem. 250, 8804–8811 (1975).

    CAS  PubMed  Google Scholar 

  20. Price, A.R. & Fogt, S.M. J. Biol. Chem. 248, 1372–1380 (1973).

    CAS  PubMed  Google Scholar 

  21. Hitzeman, R.A. & Price, A.R. J. Biol. Chem. 253, 8518–8525 (1978).

    CAS  PubMed  Google Scholar 

  22. Kraulis, P.J. J. Appl. Crystallogr. 24, 946–950 (1991).

    Article  Google Scholar 

  23. Merritt, E.A. & Murphy, M.E.P. Acta Crystallogr. A50, 869–873 (1994).

    Google Scholar 

Download references

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Pearl, L., Savva, R. The problem with pyrimidines. Nat Struct Mol Biol 3, 485–487 (1996). https://doi.org/10.1038/nsb0696-485

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