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The name is bond — H bond

Nature Structural Biology volume 6, pages 403–406 (1999)Cite this article

Abstract

The hydrogen bond plays a critical role in diverse biological phenomena. Although discovered 90 years ago, the precise chemical nature of this unique interaction has remained in dispute. A recent Compton-scattering experiment, however, strongly supports a partially covalent picture of the hydrogen bond.

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Figure 1: Early views of interactions of amide and carbonyl groups in proteins.
Figure 2: Compton scattering from an anisotropic wavefunction.
Figure 3: a, Electron momentum versus anisotropy.
Figure 4: Highly schematic representation of the hydrogen bond.

References

  1. Isaacs, E.D. et al. Phys. Rev. Lett. 82, 600– 603 (1999).

    Article  CAS  Google Scholar 

  2. Latimer, W.M. & Rodebush, W.H. J. Am. Chem. Soc. 42, 1419–1433 (1920).

    Article  CAS  Google Scholar 

  3. Pauling, L. Proc. Natl. Acad. Sci. USA. 14, 359– 362 (1928).

    Article  CAS  Google Scholar 

  4. Bernal, J.D. & Fowler, R.H. J. Chem. Phys. 1, 515–548 (1933).

    Article  CAS  Google Scholar 

  5. Ehrenburg, I. Post-war years 1945-1954. 215 (The World Publishing Company, Cleveland and New York; 1967).

    Google Scholar 

  6. Astbury, W.T & Woods, H.J. Proc. Roy. Soc. A232 , 333–394 (1933).

    Google Scholar 

  7. Bernal, J.D. & Megaw, H.D. Proc. Roy. Soc. A151 , 384–420 (1935).

    Google Scholar 

  8. Pauling L. J. Am. Chem. Soc. 57, 2680–2684 (1935).

    Article  CAS  Google Scholar 

  9. Mirsky, A.E. & Pauling, L. Proc. Natl. Acad. Sci. USA, 22, 439–447 (1936).

    Article  CAS  Google Scholar 

  10. Huggins, M.L. J. Org. Chem. 1, 407–456.(1936).

    Article  CAS  Google Scholar 

  11. Huggins, M.L. Angew. Chem. Internat. Edit. 10, 147– 152 (1971).

    Article  CAS  Google Scholar 

  12. Laszlo, P. Compr. Biochem. 34A, 209–247 (1986).

    Google Scholar 

  13. Pauling, L. & Niemann, C. J. Am. Chem. Soc. 61 , 1860–1867 (1939).

    Article  CAS  Google Scholar 

  14. Huggins, M.L. Chem. Rev. 32, 195–218 ( 1943).

    Article  CAS  Google Scholar 

  15. Derewenda, Z. S., Lee, L. & Derewenda U. J. Mol. Biol. 252, 248– 262 (1995).

    Article  CAS  Google Scholar 

  16. Wahl, M.C. & Sundaralingam, M. Trends Biochem. Sci. 22, 97–102 (1997).

    Article  CAS  Google Scholar 

  17. Williams, Brian G., ed. Compton Scattering: The Investigation of Electron Momentum Distributions (McGraw-Hill International, New York; 1977).

    Google Scholar 

Download references

Acknowledgements

The authors would like to thank E. Isaacs for commenting on an early draft of this manuscript, as well as K. Longenecker for assistance.

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Authors and Affiliations

  1. the Department of Molecular Physiology, Health Sciences Center, University of Virginia, Charlottesville, 22908, Virginia, USA

    T.W. Martin & Zygmunt S. Derewenda

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  1. T.W. Martin
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  2. Zygmunt S. Derewenda
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Martin, T., Derewenda, Z. The name is bond — H bond. Nat Struct Mol Biol 6, 403–406 (1999). https://doi.org/10.1038/8195

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