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Prized malaria drug target nailed

Nature Structural & Molecular Biology volume 10, pages 316–318 (2003)Cite this article

The structure of Plasmodium falciparum dihydrofolate reductase–thymidylate synthase, a target of clinically established antimalarial drugs, reveals the nature of inhibitor binding, drug resistance and autologous gene repression, all of which influence species-specific drug sensitivity.

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Figure 1: Host-parasite differences are more pronounced in the P. falciparum DHFR active site than the TS site.
Figure 2: Parasite-specific insertions in the P. falciparum DHFR-TS structure.

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Authors and Affiliations

  1. Department of Chemistry, University of Washington, Seattle, 98195, Washington, USA

    Pradipsinh K. Rathod

  2. Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, 75390, Texas, USA

    Margaret A. Phillips

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  1. Pradipsinh K. Rathod
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  2. Margaret A. Phillips
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Correspondence to Pradipsinh K. Rathod.

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Rathod, P., Phillips, M. Prized malaria drug target nailed. Nat Struct Mol Biol 10, 316–318 (2003). https://doi.org/10.1038/nsb0503-316

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