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Two-stepping with E1

Nature Structural Biology volume 10, pages 244246 (2003) | Download Citation

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Covalent attachment of ubiquitin-like proteins to other proteins drives numerous important physiological processes. The recent structure of an ubiquitin-like E1 enzyme provides insight into the curious assembly line–like mechanism that initiates all ubiquitin-related protein processing pathways.

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Author information

Affiliations

  1. Andrew P. VanDemark and Christopher P. Hill are in the Department of Biochemistry, University of Utah School of Medicine, 20 N 1900 E, Room 211, Salt Lake City, Utah 84103 USA.

    • Andrew P. VanDemark
    •  & Christopher P. Hill

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Correspondence to Christopher P. Hill.

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DOI

https://doi.org/10.1038/nsb0403-244

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