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Two-stepping with E1

Nature Structural & Molecular Biology volume 10, pages 244–246 (2003)Cite this article

Covalent attachment of ubiquitin-like proteins to other proteins drives numerous important physiological processes. The recent structure of an ubiquitin-like E1 enzyme provides insight into the curious assembly line–like mechanism that initiates all ubiquitin-related protein processing pathways.

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Figure 1: MoeB–MoaD and E1 structures.
Figure 2: Cartoon representation of the E1 reaction.

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Authors and Affiliations

  1. Department of Biochemistry, University of Utah School of Medicine, 20 N 1900 E, Room 211, Salt Lake City, 84103, Utah, USA

    Andrew P. VanDemark & Christopher P. Hill

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  1. Andrew P. VanDemark
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  2. Christopher P. Hill
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Correspondence to Christopher P. Hill.

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VanDemark, A., Hill, C. Two-stepping with E1. Nat Struct Mol Biol 10, 244–246 (2003). https://doi.org/10.1038/nsb0403-244

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