Function analysis of 'insulators' has led to the idea that they comprise two separable and mechanistically distinct insulating activities — one blocking enhancer cross-talk and the other barring heterochromatin spreading. However, results from two recent studies have blurred this mechanistic distinction.
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Schedl, P., Broach, J. Making good neighbors: The right fence for the right job. Nat Struct Mol Biol 10, 241–243 (2003). https://doi.org/10.1038/nsb0403-241
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DOI: https://doi.org/10.1038/nsb0403-241
