News & Views | Published:

Making good neighbors: The right fence for the right job

Nature Structural Biology volume 10, pages 241243 (2003) | Download Citation

Subjects

Function analysis of 'insulators' has led to the idea that they comprise two separable and mechanistically distinct insulating activities — one blocking enhancer cross-talk and the other barring heterochromatin spreading. However, results from two recent studies have blurred this mechanistic distinction.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Proc. Natl. Acad. Sci. USA 99, 6883–6888 (2002).

  2. 2.

    & Genetics 147, 209–221 (1997).

  3. 3.

    , & Mol. Cell 6, 1025–1035 (2000).

  4. 4.

    & Science 291, 493–495 (2001).

  5. 5.

    et al. Science 291, 495–498 (2001).

  6. 6.

    , & Genes Dev. in the press (2003).

  7. 7.

    , & Genetics 138, 387–399 (1994).

  8. 8.

    , , & Development 129, 5195–5204 (2002).

  9. 9.

    & Curr. Opin. Genet. Dev. 12, 178–187 (2002).

  10. 10.

    , , , & EMBO J. 20, 2224–2235 (2001).

  11. 11.

    , , , & Genes Dev. 16, 1540–1554 (2002).

  12. 12.

    , , , & Cell 109, 551–562 (2002).

  13. 13.

    & Mol. Cell 11, 237–248 (2003).

  14. 14.

    , & J. Cell Biol. 151, 1047–1056 (2000).

Download references

Author information

Affiliations

  1. Paul Schedl and James R. Broach are in the Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.

    • Paul Schedl
    •  & James R. Broach

Authors

  1. Search for Paul Schedl in:

  2. Search for James R. Broach in:

Corresponding authors

Correspondence to Paul Schedl or James R. Broach.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nsb0403-241

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing