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Ni and CO: more surprises

Nature Structural Biology volume 10, pages 234236 (2003) | Download Citation

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Recent structural studies of acetyl-coenzyme A synthase/carbon monoxide dehydrogenase from Moorella thermoacetica revealed a unique Cu-Ni-[Fe4-S4] active site. New data now indicate that active enzyme contains a Ni-Ni-[Fe4-S4] site. Novel chemistry is posited for the central Ni atom of this enzyme, which utilizes the toxic gas CO as a catalytic intermediate.

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References

  1. 1.

    , & J. Biol. Chem. 274, 1193–1195 (1999).

  2. 2.

    et al. Nat. Struct. Biol. 9, 966–972 (2002).

  3. 3.

    et al. J. Am. Chem. Soc. 118, 12989–12996 (1996).

  4. 4.

    , & FEMS Microbiol. Rev. 25, 455–501 (2001).

  5. 5.

    , , & Biochemistry 39, 7956–7963 (2000).

  6. 6.

    , , , & Proc. Natl. Acad. Sci. USA 98, 11973–11978 (2001).

  7. 7.

    , , , & Science 293, 1281–1285 (2001).

  8. 8.

    , , , & Science 298, 567–572 (2002).

  9. 9.

    et al. Nat. Struct. Biol. 10, 271–279 (2003).

  10. 10.

    & J. Am. Chem. Soc. 121, 9221–9222 (1999).

  11. 11.

    & Biochemistry 39, 1274–1277 (2000).

  12. 12.

    et al. Proc. Natl. Acad. Sci. USA Early Edition, 14 February 2003 (doi:10.1073/pnas0436720100).

  13. 13.

    & J. Biol. Chem. 278, 6101–6110 (2003).

  14. 14.

    & J. Am. Chem. Soc. 114, 9718–9719 (1992).

  15. 15.

    , , , & J. Am. Chem. Soc. 120, 7502–7510 (1998).

  16. 16.

    & J. Am. Chem. Soc. 119, 3959–3970 (1997).

  17. 17.

    , & J. Am. Chem. Soc. 124, 6277–6284 (2002).

  18. 18.

    , , & J. Chem. Soc. Dalton Trans. 113, 8485–8492 (1991).

  19. 19.

    , , , & Inorg. Chem. 35, 2176–2183 (1996).

Download references

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Affiliations

  1. Robert P. Hausinger is in the Department of Microbiology and Molecular Genetics and the Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824-4320, USA. hausinge@msu.edu

    • Robert P. Hausinger

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DOI

https://doi.org/10.1038/nsb0403-234

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