Recent structural studies of acetyl-coenzyme A synthase/carbon monoxide dehydrogenase from Moorella thermoacetica revealed a unique Cu-Ni-[Fe4-S4] active site. New data now indicate that active enzyme contains a Ni-Ni-[Fe4-S4] site. Novel chemistry is posited for the central Ni atom of this enzyme, which utilizes the toxic gas CO as a catalytic intermediate.
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Hausinger, R. Ni and CO: more surprises. Nat Struct Mol Biol 10, 234–236 (2003). https://doi.org/10.1038/nsb0403-234
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DOI: https://doi.org/10.1038/nsb0403-234
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