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Trading places

Protein polymerization via 3D domain swapping has been suggested to promote amyloid plaque formation. Two recent papers provide support for a role for domain swapping in the formation of highly ordered aggregates such as the fibrils characteristic of amyloid plaques.

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Figure 1: Oligomerization via domain swapping.
Figure 2: Polymerization via domain swapping.
Figure 3: A piece of polar zipper.
Figure 4


  1. Klafi, H.W. et al. Biol. Chem. Hoppe-Seyler 374, 1117–1122 (1993).

    Article  Google Scholar 

  2. Bennett, M.J., Schluneggar, M.P. & Eisenberg, D. S. Protein Sci. 4, 2455–2468 (1995).

    Article  CAS  Google Scholar 

  3. Janowski, R. et al. Nature Struct. Biol. 8, 316–320 (2001).

    Article  CAS  Google Scholar 

  4. Liu, Y, Gotte, G., Libonati, M., & Eisenberg, D. Nature Struct. Biol. 8, 211–214 (2001).

    Article  CAS  Google Scholar 

  5. Green, S.M., Gittis, A.G., Meeker, A.K. & Lattman, E.E., Nature Struct. Biol. 2, 746–751 (1995).

    Article  CAS  Google Scholar 

  6. Ealick, S.E. et al. Science 252, 698–702 (1991).

    Article  CAS  Google Scholar 

  7. Liu, Y., Hart, P.J., Schlunegger, M.P. & Eisenberg, D., Proc. Natl. Acad. Sci. USA 95, 3437–3442 (1998).

    Article  CAS  Google Scholar 

  8. Perutz, M.F., Johnson, T., Suzuki, M., & Finch, J.T. Proc. Natl. Acad. Sci. USA 91, 5355–5356 (1994).

    Article  CAS  Google Scholar 

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Newcomer, M. Trading places. Nat Struct Mol Biol 8, 282–284 (2001).

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