A coat for all sequences

A new RNA aptamer–protein co-crystal surprisingly shows that bacteriophage MS2 coat protein uses a similar set of contacts to bind both a native RNA ligand and an RNA hairpin with a different secondary structure.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Convery, M.A. et al. Nature Struct. Biol. 5, 133–139 (1998).

  2. 2

    Heus, H.A. 1997. RNA aptamers. Nature Struct. Biol. 4, 597–600.

  3. 3

    Witherell, G.W., Gott, J.M. & Uhlenbeck, O.C. Prog. Nucleic Acid Res. Mol. Biol. 40, 185–220 (1991).

  4. 4

    Tuerk, C. & Gold, L. Science 249, 505–510 (1990).

  5. 5

    Schneider, D., Tuerk, C. & Gold, L. J. Mol. Biol. 288, 862–869 (1992).

  6. 6

    Valegård, K., Murray, J.B., Stockley, P.G., Stonehouse, N.J. & Liljas, L. Nature 371, 623–626 (1994).

  7. 7

    Peabody, D.S. EMBO J. 12, 595–600 (1993).

  8. 8

    Stockley, P.G. et al. Nucleic Acids Res. 23, 2512–2518 (1995).

  9. 9

    Johansson, H.E., Liljas, L. & Uhlenbeck, O.C. Seminars in VIROLOGY 8, 176–185 (1998).

  10. 10

    Oubridge, C., Ito, N., Evans, P.R., Teo, C.H. & Nagai, K. Nature 372, 432–438 (1994).

  11. 11

    Allain, F.H.T. et al. Nature 380, 646–650 (1996).

  12. 12

    Mirmira, S.R. & Tinoco, I., Jr. Biochemistry 35, 7664–7674 (1996).

  13. 13

    Mirmira, S.R. & Tinoco, I., Jr. Biochemistry 35, 7675–7683 (1996).

  14. 14

    Valegård, K. et al. J. Mol. Biol. 270, 724–738 (1997).

  15. 15

    Borer, P.N. et al. Biochemistry 34, 6488–6503 (1995).

  16. 16

    Talbot, S.J., Goodman, S., Bates, S.R., Fishwick, C.W. & Stockley, P.G. Nucleic Acids Res. 18, 3521–3528 (1990).

  17. 17

    Wu, H.-N. & Uhlenbeck, O.C. Biochemistry 26, 8221–8227 (1987).

  18. 18

    Klimasauskas, S. & Roberts, R.J. Nucleic Acids Res. 23, 1388–1395 (1995).

  19. 19

    Rould, M.A., Perona, J.J., Söll, D. & Steitz, T.A. Science 246, 1135–1142 (1989).

  20. 20

    Hayase, Y. et al. EMBO J. 11, 4159–4165 (1992).

  21. 21

    Spingola, M. & Peabody, D.S. Nucleic Acids Res. 25, 2808–2815 (1997).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Uhlenbeck, O. A coat for all sequences. Nat Struct Mol Biol 5, 174–176 (1998). https://doi.org/10.1038/nsb0398-174

Download citation

Further reading