Stabilization of the T1 fragment of glycophorin AN through interactions with N- and O-linked glycans

NMR studies of the highly and densely glycosylated glycoprotein demonstrate that peptide–carbohydrate interactions at the 13 glycosylation sites induce well defined saccharide conformations and extended peptide backbone structures.

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References

  1. 1

    Marchesi, V.T. Semin. Hematol. 16, 3–20 (1979).

  2. 2

    Furthmayer, H. Nature 271, 519–524 (1978).

  3. 3

    Orlandi, P.A., Klotz, F.W. & Haynes, J.D. J. Cell Biol. 116, 901–909 (1992).

  4. 4

    Sim, B.K.L., Chitnis, C.E., Wasniowska, K., Hadley, T.J. & Miller, L.H. Science 264, 1941–1944 (1994).

  5. 5

    Anderson, R.A. & Marchesi, V.T. Nature 318, 295–298 (1985).

  6. 6

    King, M.-J. TIGG 3, 315–326 (1991).

  7. 7

    Fukuda, M., Lauffenburger, M., Sasaki, H., Rogers, M.E. & Dell, A. J. Biol. Chem. 262, 11952–11957 (1987).

  8. 8

    Wyss, D.F. et al. Science 269, 1273–1278 (1995).

  9. 9

    Fletcher, C.M., Harrison, R.A., Lachmann, P.J. & Neuhaus, D. Structure 2, 185–199 (1994).

  10. 10

    de Beer, T. et al. FEBS Lett 348, 1–6 (1994).

  11. 11

    Jenthoft, N. Trends Biochem. Sci. 15, 291–294 (1990).

  12. 12

    Dill, K., Hu, S., Berman, E., Pavia, A.A., Lacombe, J.M. J. Protein Chem. 9, 129–136 (1990).

  13. 13

    Duben, A.J. & Bush, C.A. Arch. Biochem. Biophys. 225, 1–15 (1983).

  14. 14

    Meyer, B., Zsiska, M. & Stuike-Prill, R. in Computer Simulations in Condensed Matter Physics IV, (eds Landau, D.P., Mon, K.M. & Schuttler, H.B.) 90–112 (Springer-Verlag, Berlin, 1993).

  15. 15

    Butenhof, K.L. & Gerken, T.A. Biochemistry 32, 2650–2663 (1993).

  16. 16

    Stuike-Prill, R. & Meyer, B. Eur. J. Biochem. 194, 903–919 (1990).

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Pieper, J., Ott, K. & Meyer, B. Stabilization of the T1 fragment of glycophorin AN through interactions with N- and O-linked glycans. Nat Struct Mol Biol 3, 228–232 (1996). https://doi.org/10.1038/nsb0396-228

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