Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Stabilization of the T1 fragment of glycophorin AN through interactions with N- and O-linked glycans

NMR studies of the highly and densely glycosylated glycoprotein demonstrate that peptide–carbohydrate interactions at the 13 glycosylation sites induce well defined saccharide conformations and extended peptide backbone structures.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Marchesi, V.T. Semin. Hematol. 16, 3–20 (1979).

    CAS  PubMed  Google Scholar 

  2. Furthmayer, H. Nature 271, 519–524 (1978).

    Article  Google Scholar 

  3. Orlandi, P.A., Klotz, F.W. & Haynes, J.D. J. Cell Biol. 116, 901–909 (1992).

    Article  CAS  Google Scholar 

  4. Sim, B.K.L., Chitnis, C.E., Wasniowska, K., Hadley, T.J. & Miller, L.H. Science 264, 1941–1944 (1994).

    Article  CAS  Google Scholar 

  5. Anderson, R.A. & Marchesi, V.T. Nature 318, 295–298 (1985).

    Article  CAS  Google Scholar 

  6. King, M.-J. TIGG 3, 315–326 (1991).

    Article  CAS  Google Scholar 

  7. Fukuda, M., Lauffenburger, M., Sasaki, H., Rogers, M.E. & Dell, A. J. Biol. Chem. 262, 11952–11957 (1987).

    CAS  PubMed  Google Scholar 

  8. Wyss, D.F. et al. Science 269, 1273–1278 (1995).

    Article  CAS  Google Scholar 

  9. Fletcher, C.M., Harrison, R.A., Lachmann, P.J. & Neuhaus, D. Structure 2, 185–199 (1994).

    Article  CAS  Google Scholar 

  10. de Beer, T. et al. FEBS Lett 348, 1–6 (1994).

    Article  CAS  Google Scholar 

  11. Jenthoft, N. Trends Biochem. Sci. 15, 291–294 (1990).

    Article  Google Scholar 

  12. Dill, K., Hu, S., Berman, E., Pavia, A.A., Lacombe, J.M. J. Protein Chem. 9, 129–136 (1990).

    Article  CAS  Google Scholar 

  13. Duben, A.J. & Bush, C.A. Arch. Biochem. Biophys. 225, 1–15 (1983).

    Article  CAS  Google Scholar 

  14. Meyer, B., Zsiska, M. & Stuike-Prill, R. in Computer Simulations in Condensed Matter Physics IV, (eds Landau, D.P., Mon, K.M. & Schuttler, H.B.) 90–112 (Springer-Verlag, Berlin, 1993).

    Google Scholar 

  15. Butenhof, K.L. & Gerken, T.A. Biochemistry 32, 2650–2663 (1993).

    Article  CAS  Google Scholar 

  16. Stuike-Prill, R. & Meyer, B. Eur. J. Biochem. 194, 903–919 (1990).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pieper, J., Ott, KH. & Meyer, B. Stabilization of the T1 fragment of glycophorin AN through interactions with N- and O-linked glycans. Nat Struct Mol Biol 3, 228–232 (1996). https://doi.org/10.1038/nsb0396-228

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsb0396-228

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing