Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cure for a crisis?

Nature Structural Biology volume 3, pages 218–221 (1996)Cite this article

The first look at the three-dimensional structure of an essential penicillin binding protein from a human pathogen, and its complex with a β-lactam antibiotic provides hope for the future design of improved antibiotics.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Pares, S., Mouz, N., Pétillot, Y., Hakenbeck, R. & Dideberg, O. Nature Struct. Biol. 3, 284–289 (1996).

    Article  CAS  Google Scholar 

  2. Kucers, A. & Bennett, N.M. in The use of antibiotics: a comprehensive review with clinical emphasis 1–585 (William Heinemann Medical Books, London, 1987).

    Google Scholar 

  3. Neu, H.C. Science 257, 1064–1073 (1992).

    Article  CAS  Google Scholar 

  4. Chin, G.J. & Marx, J. (eds.) Science 264, 360–393 (1994).

    Article  Google Scholar 

  5. Weidel, W. & Pelzer, H. Adv. Enzymol. 26, 193–232 (1964).

    Google Scholar 

  6. van Heijenoort, J. in Bacterial cell wall (eds. Ghuysen, J.-M. & Hakenbeck, R.) 39–54 (Elsevier Science B.V., Amsterdam, 1994).

    Book  Google Scholar 

  7. Höltje, J.-V. & Schwarz, U. in Molecular Cytology of Escherichia coli 77–119 (Academic Press, London, 1985).

    Google Scholar 

  8. Matsuhashi, M. in Bacterial cell wall (eds. Ghuysen, J.-M. & Hakenbeck, R.) 55–71 (Elsevier Science B.V., Amsterdam, 1994).

    Book  Google Scholar 

  9. Jamin, M., Bamblon, C., Millier, S., Hakenbeck, R. & Frère, J.-M. Biochem. J. 292, 735–741 (1993).

    Article  CAS  Google Scholar 

  10. Kitano, K., Tuomanen, E. & Tomasz, A. FEMS Microbiol. Lett. 7, 759–765 (1986).

    Google Scholar 

  11. Kelly, J.A. et al. J. Biol. Chem. 260, 6449–6458 (1985).

    CAS  PubMed  Google Scholar 

  12. Kelly, J.A. & Kuzin, A.P. J. Mol. Biol. 254, 223–236 (1995).

    Article  CAS  Google Scholar 

  13. Strynadka, N.L. et al. Nature Struct. Biol. 3, 290–297 (1996).

    Article  CAS  Google Scholar 

  14. Service, R.F. Science 270, 724–727 (1995).

    Article  CAS  Google Scholar 

  15. Gale, E.F.E., Cundliffe, E., Reynolds, P.E., Richmond, M.H. & Waring, M.J. in The molecular basis of antibiotic action 49–120 (John Wiley & Sons, New York, 1972).

    Google Scholar 

  16. Fan, C., Moews, P.C., Walsh, C.T. & Knox, J.R. Science 266, 439–443 (1994).

    Article  CAS  Google Scholar 

  17. Benson, T.E., Filman, D.J., Walsh, C.T. & Hogle, J.M. Nature Struct. Biol. 2, 644–653 (1995).

    Article  CAS  Google Scholar 

  18. Benson, T.E., Walsh, C.T. & Hogle, J.M. Structure 4, 47–54 (1996).

    Article  CAS  Google Scholar 

  19. Romeis, T. & Höltje, J.-V. Eur. J. Biochemi. 224, 597–604 (1994).

    Article  CAS  Google Scholar 

  20. Thunnissen, A.M.W.H. et al. Nature 367, 750–753 (1994).

    Article  CAS  Google Scholar 

  21. Thunnissen, A.-M.W.H. PhD. Thesis, Groningen Universtiy (1995).

    Google Scholar 

  22. Wientjes, F. & Nanninga, N. J.Bacteriol. 171, 3412–3419 (1989).

    Article  CAS  Google Scholar 

  23. Schleifer, K.H. Meths Enzymol. 18, 123–156 (1985).

    CAS  Google Scholar 

  24. Labischinski, H. & Maidhof, H. in Bacterial cell wall (eds. Ghuysen, J.-M. & Hakenbeck, R.) 23–38 (Elsevier Science B.V., Amsterdam, 1994).

    Book  Google Scholar 

  25. Glauner, B., Höltje, J.-V. & Schwarz, U. J. Biol. Chem. 263, 10088–10095 (1988).

    CAS  PubMed  Google Scholar 

  26. Garcia-Bustos, J.F., Chait, B.T. & Tomasz, A. J. Biol. Chem. 262, 15400–15405 (1987).

    CAS  PubMed  Google Scholar 

Download references

Author information

Author notes

  1. Andy-Mark W. H. Thunnissen

    Present address: Melvin Calvin Laboratory, Structural Biology Division, Chemistry Department, University of California at Berkeley, Berkeley, California, 94720, USA

Authors and Affiliations

  1. Laboratory of Biophysical Chemistry and BIOSON Research Institute Department of Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands

    Andy-Mark W. H. Thunnissen & Bauke W. Dijkstra

Authors
  1. Andy-Mark W. H. Thunnissen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bauke W. Dijkstra
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Thunnissen, AM., Dijkstra, B. Cure for a crisis?. Nat Struct Mol Biol 3, 218–221 (1996). https://doi.org/10.1038/nsb0396-218

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsb0396-218

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing